Abstract

Frequent pUL27 Variations in HIV-Infected Patients

Drug-resistant isolates of human cytomegalovirus (HCMV) have led to the development of new anti- HCMV drugs. Maribavir (MBV) is a novel inhibitor of the HCMV viral kinase. Resistance to MBV is mapped to gene UL27, a viral nuclear protein. In this study, we investigated UL27 polymorphisms in MBV-naive HIV-positive and HCMV congenitally infected clinical samples.


Author(s):

Azam Mirarab



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